| Immokalee to Southern Pines (North Carolina) | 617.48 mi (993.74 km) |
| Immokalee to Southfield (Michigan) | 1,113.87 mi (1,792.60 km) |
| Immokalee to Southgate (Michigan) | 1,094.90 mi (1,762.08 km) |
| Immokalee to Southlake (Texas) | 1,044.56 mi (1,681.06 km) |
| Immokalee to Spanaway (Washington) | 2,637.86 mi (4,245.23 km) |
| Immokalee to Spanish Fork (Utah) | 1,971.28 mi (3,172.47 km) |
| Immokalee to Spanish Lake (Missouri) | 994.26 mi (1,600.11 km) |
| Immokalee to Spanish Springs (Nevada) | 2,374.21 mi (3,820.92 km) |
| Immokalee to Sparks (Nevada) | 2,375.58 mi (3,823.12 km) |
| Immokalee to Spartanburg (South Carolina) | 589.35 mi (948.46 km) |
| Immokalee to Spearfish (South Dakota) | 1,762.29 mi (2,836.13 km) |
| Immokalee to Speedway (Indiana) | 964.50 mi (1,552.21 km) |
| Immokalee to Spencer (Iowa) | 1,389.30 mi (2,235.86 km) |
| Immokalee to Spokane (Washington) | 2,434.22 mi (3,917.50 km) |
| Immokalee to Spokane Valley (Washington) | 2,425.67 mi (3,903.74 km) |
