| Humacao to University Place (Washington) | 3,755.55 mi (6,043.98 km) |
| Humacao to Upland (California) | 3,360.62 mi (5,408.40 km) |
| Humacao to Upper Arlington (Ohio) | 1,828.00 mi (2,941.89 km) |
| Humacao to Upper Grand Lagoon (Florida) | 1,501.47 mi (2,416.38 km) |
| Humacao to Upper Montclair (New Jersey) | 1,644.80 mi (2,647.04 km) |
| Humacao to Urbana (Illinois) | 2,019.08 mi (3,249.40 km) |
| Humacao to Urbana (Maryland) | 1,617.66 mi (2,603.37 km) |
| Humacao to Urbana (Ohio) | 1,855.46 mi (2,986.08 km) |
| Humacao to Urbandale (Iowa) | 2,311.99 mi (3,720.79 km) |
| Humacao to Utica (New York) | 1,809.06 mi (2,911.40 km) |
| Humacao to Uvalde (Texas) | 2,270.63 mi (3,654.22 km) |
| Humacao to Vacaville (California) | 3,629.13 mi (5,840.52 km) |
| Humacao to Vadnais Heights (Minnesota) | 2,431.45 mi (3,913.04 km) |
| Humacao to Vail (Arizona) | 2,943.17 mi (4,736.58 km) |
| Humacao to Valdosta (Georgia) | 1,401.76 mi (2,255.91 km) |
