| Humacao to Superior (Colorado) | 2,779.32 mi (4,472.88 km) |
| Humacao to Superior (Wisconsin) | 2,472.67 mi (3,979.38 km) |
| Humacao to Surprise (Arizona) | 3,060.48 mi (4,925.37 km) |
| Humacao to Susanville (California) | 3,575.67 mi (5,754.49 km) |
| Humacao to Sussex (Wisconsin) | 2,165.32 mi (3,484.75 km) |
| Humacao to Suwanee (Georgia) | 1,572.37 mi (2,530.48 km) |
| Humacao to Swansea (Illinois) | 2,023.64 mi (3,256.74 km) |
| Humacao to Sweetwater (Florida) | 1,070.05 mi (1,722.08 km) |
| Humacao to Sweetwater (Texas) | 2,361.87 mi (3,801.06 km) |
| Humacao to Sycamore (Illinois) | 2,126.41 mi (3,422.12 km) |
| Humacao to Sylacauga (Alabama) | 1,636.82 mi (2,634.20 km) |
| Humacao to Sylvania (Ohio) | 1,939.55 mi (3,121.41 km) |
| Humacao to Syosset (New York) | 1,630.94 mi (2,624.74 km) |
| Humacao to Syracuse (New York) | 1,822.52 mi (2,933.07 km) |
| Humacao to Syracuse (Utah) | 3,148.69 mi (5,067.33 km) |
