| Humacao to Storm Lake (Iowa) | 2,411.35 mi (3,880.69 km) |
| Humacao to Storrs (Connecticut) | 1,677.92 mi (2,700.35 km) |
| Humacao to Stoughton (Wisconsin) | 2,190.74 mi (3,525.66 km) |
| Humacao to Stow (Ohio) | 1,839.74 mi (2,960.78 km) |
| Humacao to Streamwood (Illinois) | 2,109.07 mi (3,394.22 km) |
| Humacao to Streator (Illinois) | 2,090.79 mi (3,364.79 km) |
| Humacao to Streetsboro (Ohio) | 1,840.70 mi (2,962.32 km) |
| Humacao to Strongsville (Ohio) | 1,859.30 mi (2,992.26 km) |
| Humacao to Stuart (Florida) | 1,110.29 mi (1,786.84 km) |
| Humacao to Stuarts Draft (Virginia) | 1,587.56 mi (2,554.93 km) |
| Humacao to Sturgis (Michigan) | 2,000.63 mi (3,219.71 km) |
| Humacao to Suamico (Wisconsin) | 2,235.69 mi (3,597.99 km) |
| Humacao to Sudley (Virginia) | 1,589.05 mi (2,557.34 km) |
| Humacao to Suffern (New York) | 1,661.33 mi (2,673.66 km) |
| Humacao to Suffolk (Virginia) | 1,440.33 mi (2,317.98 km) |
