| Humacao to Southern Pines (North Carolina) | 1,442.15 mi (2,320.91 km) |
| Humacao to Southfield (Michigan) | 1,967.56 mi (3,166.48 km) |
| Humacao to Southgate (Michigan) | 1,950.84 mi (3,139.58 km) |
| Humacao to Southlake (Texas) | 2,192.23 mi (3,528.05 km) |
| Humacao to Spanaway (Washington) | 3,748.21 mi (6,032.17 km) |
| Humacao to Spanish Fork (Utah) | 3,108.73 mi (5,003.02 km) |
| Humacao to Spanish Lake (Missouri) | 2,043.12 mi (3,288.09 km) |
| Humacao to Spanish Springs (Nevada) | 3,518.34 mi (5,662.23 km) |
| Humacao to Sparks (Nevada) | 3,519.93 mi (5,664.79 km) |
| Humacao to Spartanburg (South Carolina) | 1,524.19 mi (2,452.95 km) |
| Humacao to Spearfish (South Dakota) | 2,846.00 mi (4,580.19 km) |
| Humacao to Speedway (Indiana) | 1,929.16 mi (3,104.68 km) |
| Humacao to Spencer (Iowa) | 2,429.94 mi (3,910.61 km) |
| Humacao to Spokane (Washington) | 3,532.11 mi (5,684.38 km) |
| Humacao to Spokane Valley (Washington) | 3,523.19 mi (5,670.03 km) |
