| Humacao to Smyrna (Delaware) | 1,574.05 mi (2,533.19 km) |
| Humacao to Smyrna (Georgia) | 1,584.11 mi (2,549.38 km) |
| Humacao to Smyrna (Tennessee) | 1,763.91 mi (2,838.74 km) |
| Humacao to Snellville (Georgia) | 1,560.94 mi (2,512.09 km) |
| Humacao to Snoqualmie (Washington) | 3,728.08 mi (5,999.77 km) |
| Humacao to Snyder (Texas) | 2,394.66 mi (3,853.83 km) |
| Humacao to Socastee (South Carolina) | 1,347.65 mi (2,168.84 km) |
| Humacao to Socorro (Texas) | 2,682.04 mi (4,316.32 km) |
| Humacao to Soddy-Daisy (Tennessee) | 1,673.99 mi (2,694.02 km) |
| Humacao to Solana Beach (California) | 3,330.63 mi (5,360.13 km) |
| Humacao to Soledad (California) | 3,582.17 mi (5,764.95 km) |
| Humacao to Solon (Ohio) | 1,851.84 mi (2,980.25 km) |
| Humacao to Somers Point (New Jersey) | 1,554.19 mi (2,501.22 km) |
| Humacao to Somerset (Kentucky) | 1,734.83 mi (2,791.95 km) |
| Humacao to Somerset (New Jersey) | 1,628.65 mi (2,621.05 km) |
