| Humacao to Seymour (Tennessee) | 1,643.43 mi (2,644.85 km) |
| Humacao to Shady Hills (Florida) | 1,273.90 mi (2,050.15 km) |
| Humacao to Shafter (California) | 3,456.74 mi (5,563.09 km) |
| Humacao to Shaker Heights (Ohio) | 1,860.06 mi (2,993.48 km) |
| Humacao to Shakopee (Minnesota) | 2,433.72 mi (3,916.70 km) |
| Humacao to Sharon (Pennsylvania) | 1,815.96 mi (2,922.51 km) |
| Humacao to Sharonville (Ohio) | 1,835.71 mi (2,954.30 km) |
| Humacao to Shasta Lake (California) | 3,669.89 mi (5,906.11 km) |
| Humacao to Shawnee (Kansas) | 2,256.20 mi (3,631.00 km) |
| Humacao to Shawnee (Oklahoma) | 2,244.23 mi (3,611.74 km) |
| Humacao to Sheboygan (Wisconsin) | 2,178.80 mi (3,506.44 km) |
| Humacao to Shelby (North Carolina) | 1,526.54 mi (2,456.73 km) |
| Humacao to Shelbyville (Indiana) | 1,898.91 mi (3,055.99 km) |
| Humacao to Shelbyville (Kentucky) | 1,813.16 mi (2,918.00 km) |
| Humacao to Shelbyville (Tennessee) | 1,740.43 mi (2,800.96 km) |
