| Humacao to Security-Widefield (Colorado) | 2,728.16 mi (4,390.56 km) |
| Humacao to Sedalia (Missouri) | 2,173.16 mi (3,497.36 km) |
| Humacao to Sedro-Woolley (Washington) | 3,761.10 mi (6,052.91 km) |
| Humacao to Seguin (Texas) | 2,170.25 mi (3,492.68 km) |
| Humacao to Selden (New York) | 1,627.26 mi (2,618.83 km) |
| Humacao to Selma (Alabama) | 1,645.85 mi (2,648.74 km) |
| Humacao to Selma (California) | 3,487.53 mi (5,612.63 km) |
| Humacao to Selma (Texas) | 2,190.37 mi (3,525.05 km) |
| Humacao to Seminole (Florida) | 1,267.62 mi (2,040.03 km) |
| Humacao to Seven Hills (Ohio) | 1,858.40 mi (2,990.80 km) |
| Humacao to Seven Oaks (South Carolina) | 1,448.82 mi (2,331.66 km) |
| Humacao to Severn (Maryland) | 1,589.74 mi (2,558.44 km) |
| Humacao to Severna Park (Maryland) | 1,583.65 mi (2,548.64 km) |
| Humacao to Sevierville (Tennessee) | 1,635.79 mi (2,632.56 km) |
| Humacao to Seymour (Indiana) | 1,874.52 mi (3,016.74 km) |
