| Humacao to Scottsboro (Alabama) | 1,686.28 mi (2,713.81 km) |
| Humacao to Scottsdale (Arizona) | 3,027.21 mi (4,871.83 km) |
| Humacao to Scranton (Pennsylvania) | 1,708.77 mi (2,749.99 km) |
| Humacao to Seabrook (Maryland) | 1,584.06 mi (2,549.30 km) |
| Humacao to Seabrook (Texas) | 1,999.38 mi (3,217.69 km) |
| Humacao to Seaford (New York) | 1,621.09 mi (2,608.88 km) |
| Humacao to Seagoville (Texas) | 2,152.09 mi (3,463.45 km) |
| Humacao to Seal Beach (California) | 3,381.83 mi (5,442.52 km) |
| Humacao to Searcy (Arkansas) | 1,977.52 mi (3,182.51 km) |
| Humacao to Seaside (California) | 3,609.64 mi (5,809.15 km) |
| Humacao to SeaTac (Washington) | 3,747.62 mi (6,031.21 km) |
| Humacao to Seattle (Washington) | 3,751.45 mi (6,037.38 km) |
| Humacao to Sebastian (Florida) | 1,144.03 mi (1,841.13 km) |
| Humacao to Sebring (Florida) | 1,184.09 mi (1,905.60 km) |
| Humacao to Secaucus (New Jersey) | 1,638.35 mi (2,636.67 km) |
