| Humacao to Santa Rosa (California) | 3,669.57 mi (5,905.60 km) |
| Humacao to Santaquin (Utah) | 3,114.02 mi (5,011.53 km) |
| Humacao to Santee (California) | 3,314.10 mi (5,333.52 km) |
| Humacao to Sapulpa (Oklahoma) | 2,219.12 mi (3,571.33 km) |
| Humacao to Saraland (Alabama) | 1,647.51 mi (2,651.42 km) |
| Humacao to Sarasota (Florida) | 1,238.31 mi (1,992.87 km) |
| Humacao to Sarasota Springs (Florida) | 1,233.62 mi (1,985.32 km) |
| Humacao to Saratoga (California) | 3,624.91 mi (5,833.73 km) |
| Humacao to Saratoga Springs (New York) | 1,783.26 mi (2,869.88 km) |
| Humacao to Saratoga Springs (Utah) | 3,127.03 mi (5,032.47 km) |
| Humacao to Sartell (Minnesota) | 2,498.97 mi (4,021.71 km) |
| Humacao to Satellite Beach (Florida) | 1,165.03 mi (1,874.93 km) |
| Humacao to Sauk Rapids (Minnesota) | 2,495.58 mi (4,016.25 km) |
| Humacao to Sault Ste. Marie (Michigan) | 2,224.53 mi (3,580.03 km) |
| Humacao to Savage (Minnesota) | 2,428.56 mi (3,908.39 km) |
