| Humacao to Sanford (Maine) | 1,769.75 mi (2,848.13 km) |
| Humacao to Sanford (North Carolina) | 1,450.21 mi (2,333.89 km) |
| Humacao to Sanger (California) | 3,485.37 mi (5,609.16 km) |
| Humacao to Santa Ana (California) | 3,370.87 mi (5,424.90 km) |
| Humacao to Santa Barbara (California) | 3,479.64 mi (5,599.94 km) |
| Humacao to Santa Clara (California) | 3,622.33 mi (5,829.58 km) |
| Humacao to Santa Clara (Oregon) | 3,743.28 mi (6,024.22 km) |
| Humacao to Santa Clarita (California) | 3,410.08 mi (5,487.99 km) |
| Humacao to Santa Cruz (California) | 3,623.59 mi (5,831.60 km) |
| Humacao to Santa Fe (New Mexico) | 2,729.08 mi (4,392.03 km) |
| Humacao to Santa Fe (Texas) | 2,000.17 mi (3,218.97 km) |
| Humacao to Santa Fe Springs (California) | 3,382.38 mi (5,443.42 km) |
| Humacao to Santa Maria (California) | 3,523.28 mi (5,670.17 km) |
| Humacao to Santa Monica (California) | 3,406.81 mi (5,482.74 km) |
| Humacao to Santa Paula (California) | 3,442.03 mi (5,539.41 km) |
