| Humacao to Orangevale (California) | 3,591.61 mi (5,780.13 km) |
| Humacao to Orchards (Washington) | 3,733.61 mi (6,008.66 km) |
| Humacao to Orcutt (California) | 3,521.76 mi (5,667.73 km) |
| Humacao to Oregon (Ohio) | 1,927.59 mi (3,102.16 km) |
| Humacao to Oregon (Wisconsin) | 2,196.89 mi (3,535.55 km) |
| Humacao to Oregon City (Oregon) | 3,731.99 mi (6,006.06 km) |
| Humacao to Orem (Utah) | 3,115.20 mi (5,013.43 km) |
| Humacao to Orinda (California) | 3,637.22 mi (5,853.54 km) |
| Humacao to Orland Park (Illinois) | 2,077.42 mi (3,343.29 km) |
| Humacao to Orlando (Florida) | 1,213.78 mi (1,953.39 km) |
| Humacao to Ormond Beach (Florida) | 1,233.63 mi (1,985.33 km) |
| Humacao to Oro Valley (Arizona) | 2,963.40 mi (4,769.13 km) |
| Humacao to Oroville (California) | 3,616.72 mi (5,820.55 km) |
| Humacao to Oshkosh (Wisconsin) | 2,221.32 mi (3,574.87 km) |
| Humacao to Oskaloosa (Iowa) | 2,250.30 mi (3,621.51 km) |
