| Humacao to Olympia Heights (Florida) | 1,066.30 mi (1,716.04 km) |
| Humacao to Omaha (Nebraska) | 2,394.38 mi (3,853.38 km) |
| Humacao to On Top of the World Designated Place (Florida) | 1,285.61 mi (2,068.99 km) |
| Humacao to Onalaska (Wisconsin) | 2,309.00 mi (3,715.97 km) |
| Humacao to Oneida (New York) | 1,815.72 mi (2,922.13 km) |
| Humacao to Oneonta (New York) | 1,764.76 mi (2,840.11 km) |
| Humacao to Ontario (California) | 3,357.03 mi (5,402.62 km) |
| Humacao to Ontario (Oregon) | 3,442.96 mi (5,540.91 km) |
| Humacao to Opa-locka (Florida) | 1,067.13 mi (1,717.38 km) |
| Humacao to Opelika (Alabama) | 1,574.36 mi (2,533.68 km) |
| Humacao to Opelousas (Louisiana) | 1,854.31 mi (2,984.22 km) |
| Humacao to Orange (California) | 3,367.84 mi (5,420.02 km) |
| Humacao to Orange (Texas) | 1,938.81 mi (3,120.21 km) |
| Humacao to Orange City (Florida) | 1,228.65 mi (1,977.32 km) |
| Humacao to Orangeburg (South Carolina) | 1,410.44 mi (2,269.88 km) |
