| Humacao to Enterprise (Nevada) | 3,240.28 mi (5,214.72 km) |
| Humacao to Enumclaw (Washington) | 3,729.85 mi (6,002.62 km) |
| Humacao to Ephrata (Pennsylvania) | 1,642.49 mi (2,643.34 km) |
| Humacao to Erie (Colorado) | 2,776.12 mi (4,467.73 km) |
| Humacao to Erie (Pennsylvania) | 1,855.97 mi (2,986.89 km) |
| Humacao to Erlanger (Kentucky) | 1,828.53 mi (2,942.74 km) |
| Humacao to Escanaba (Michigan) | 2,262.57 mi (3,641.26 km) |
| Humacao to Escondido (California) | 3,320.77 mi (5,344.26 km) |
| Humacao to Española (New Mexico) | 2,740.16 mi (4,409.85 km) |
| Humacao to Essex (Maryland) | 1,593.92 mi (2,565.17 km) |
| Humacao to Essex Junction (Vermont) | 1,868.14 mi (3,006.48 km) |
| Humacao to Estelle (Louisiana) | 1,727.08 mi (2,779.47 km) |
| Humacao to Estero (Florida) | 1,168.86 mi (1,881.09 km) |
| Humacao to Euclid (Ohio) | 1,865.75 mi (3,002.64 km) |
| Humacao to Eufaula (Alabama) | 1,534.23 mi (2,469.11 km) |
