| Humacao to Elyria (Ohio) | 1,871.15 mi (3,011.32 km) |
| Humacao to Emeryville (California) | 3,643.14 mi (5,863.06 km) |
| Humacao to Emmaus (Pennsylvania) | 1,650.09 mi (2,655.56 km) |
| Humacao to Emporia (Kansas) | 2,299.53 mi (3,700.74 km) |
| Humacao to Encinitas (California) | 3,331.15 mi (5,360.97 km) |
| Humacao to Endicott (New York) | 1,760.91 mi (2,833.92 km) |
| Humacao to Endwell (New York) | 1,761.37 mi (2,834.65 km) |
| Humacao to Englewood (Colorado) | 2,764.03 mi (4,448.28 km) |
| Humacao to Englewood (Florida) | 1,216.36 mi (1,957.54 km) |
| Humacao to Englewood (New Jersey) | 1,643.93 mi (2,645.65 km) |
| Humacao to Englewood (Ohio) | 1,861.94 mi (2,996.51 km) |
| Humacao to Enid (Oklahoma) | 2,320.14 mi (3,733.91 km) |
| Humacao to Ennis (Texas) | 2,149.27 mi (3,458.92 km) |
| Humacao to Ensley (Florida) | 1,593.64 mi (2,564.71 km) |
| Humacao to Enterprise (Alabama) | 1,547.13 mi (2,489.87 km) |
