| Humacao to Effingham (Illinois) | 1,988.13 mi (3,199.59 km) |
| Humacao to Eggertsville (New York) | 1,875.25 mi (3,017.92 km) |
| Humacao to Egypt Lake-Leto (Florida) | 1,258.53 mi (2,025.41 km) |
| Humacao to El Cajon (California) | 3,312.36 mi (5,330.73 km) |
| Humacao to El Campo (Texas) | 2,064.72 mi (3,322.84 km) |
| Humacao to El Centro (California) | 3,231.23 mi (5,200.16 km) |
| Humacao to El Cerrito (California) | 3,644.18 mi (5,864.74 km) |
| Humacao to El Dorado (Arkansas) | 1,959.63 mi (3,153.72 km) |
| Humacao to El Dorado (Kansas) | 2,312.63 mi (3,721.82 km) |
| Humacao to El Dorado Hills (California) | 3,582.29 mi (5,765.14 km) |
| Humacao to El Mirage (Arizona) | 3,052.48 mi (4,912.49 km) |
| Humacao to El Monte (California) | 3,381.35 mi (5,441.75 km) |
| Humacao to El Paso (Texas) | 2,694.50 mi (4,336.38 km) |
| Humacao to El Paso de Robles (California) | 3,539.18 mi (5,695.76 km) |
| Humacao to El Reno (Oklahoma) | 2,301.17 mi (3,703.37 km) |
