| Humacao to Des Plaines (Illinois) | 2,099.65 mi (3,379.06 km) |
| Humacao to Desert Hot Springs (California) | 3,295.84 mi (5,304.14 km) |
| Humacao to DeSoto (Texas) | 2,168.19 mi (3,489.37 km) |
| Humacao to Destin (Florida) | 1,547.14 mi (2,489.88 km) |
| Humacao to Destrehan (Louisiana) | 1,744.89 mi (2,808.12 km) |
| Humacao to Detroit (Michigan) | 1,957.59 mi (3,150.44 km) |
| Humacao to Diamond Bar (California) | 3,368.73 mi (5,421.45 km) |
| Humacao to Diamond Springs (California) | 3,571.20 mi (5,747.29 km) |
| Humacao to Dickinson (North Dakota) | 2,883.54 mi (4,640.61 km) |
| Humacao to Dickinson (Texas) | 1,999.06 mi (3,217.17 km) |
| Humacao to Dickson (Tennessee) | 1,804.88 mi (2,904.67 km) |
| Humacao to Difficult Run (Virginia) | 1,592.00 mi (2,562.07 km) |
| Humacao to Dinuba (California) | 3,475.43 mi (5,593.17 km) |
| Humacao to Discovery Bay (California) | 3,605.93 mi (5,803.19 km) |
| Humacao to Dix Hills (New York) | 1,627.42 mi (2,619.08 km) |
