| Hopkinsville to Superior (Colorado) | 979.43 mi (1,576.23 km) |
| Hopkinsville to Superior (Wisconsin) | 720.81 mi (1,160.03 km) |
| Hopkinsville to Surprise (Arizona) | 1,421.59 mi (2,287.84 km) |
| Hopkinsville to Susanville (California) | 1,794.92 mi (2,888.64 km) |
| Hopkinsville to Sussex (Wisconsin) | 436.82 mi (703.00 km) |
| Hopkinsville to Suwanee (Georgia) | 271.82 mi (437.45 km) |
| Hopkinsville to Swansea (Illinois) | 181.12 mi (291.48 km) |
| Hopkinsville to Sweetwater (Florida) | 870.89 mi (1,401.56 km) |
| Hopkinsville to Sweetwater (Texas) | 793.70 mi (1,277.33 km) |
| Hopkinsville to Sycamore (Illinois) | 362.10 mi (582.74 km) |
| Hopkinsville to Sylacauga (Alabama) | 262.09 mi (421.80 km) |
| Hopkinsville to Sylvania (Ohio) | 392.24 mi (631.26 km) |
| Hopkinsville to Syosset (New York) | 799.78 mi (1,287.11 km) |
| Hopkinsville to Syracuse (New York) | 736.60 mi (1,185.44 km) |
| Hopkinsville to Syracuse (Utah) | 1,348.58 mi (2,170.33 km) |
