| Hopkinsville to Southern Pines (North Carolina) | 465.14 mi (748.58 km) |
| Hopkinsville to Southfield (Michigan) | 449.39 mi (723.23 km) |
| Hopkinsville to Southgate (Michigan) | 434.97 mi (700.02 km) |
| Hopkinsville to Southlake (Texas) | 609.88 mi (981.51 km) |
| Hopkinsville to Spanaway (Washington) | 1,910.63 mi (3,074.87 km) |
| Hopkinsville to Spanish Fork (Utah) | 1,322.20 mi (2,127.88 km) |
| Hopkinsville to Spanish Lake (Missouri) | 200.90 mi (323.31 km) |
| Hopkinsville to Spanish Springs (Nevada) | 1,748.21 mi (2,813.47 km) |
| Hopkinsville to Sparks (Nevada) | 1,751.09 mi (2,818.11 km) |
| Hopkinsville to Spartanburg (South Carolina) | 337.15 mi (542.58 km) |
| Hopkinsville to Spearfish (South Dakota) | 1,003.58 mi (1,615.10 km) |
| Hopkinsville to Speedway (Indiana) | 214.81 mi (345.70 km) |
| Hopkinsville to Spencer (Iowa) | 595.38 mi (958.17 km) |
| Hopkinsville to Spokane (Washington) | 1,690.58 mi (2,720.72 km) |
| Hopkinsville to Spokane Valley (Washington) | 1,681.59 mi (2,706.26 km) |
