| Homosassa Springs to Superior (Colorado) | 1,494.98 mi (2,405.94 km) |
| Homosassa Springs to Superior (Wisconsin) | 1,338.62 mi (2,154.30 km) |
| Homosassa Springs to Surprise (Arizona) | 1,792.18 mi (2,884.23 km) |
| Homosassa Springs to Susanville (California) | 2,287.82 mi (3,681.89 km) |
| Homosassa Springs to Sussex (Wisconsin) | 1,038.71 mi (1,671.64 km) |
| Homosassa Springs to Suwanee (Georgia) | 373.02 mi (600.31 km) |
| Homosassa Springs to Swansea (Illinois) | 796.85 mi (1,282.41 km) |
| Homosassa Springs to Sweetwater (Florida) | 248.11 mi (399.30 km) |
| Homosassa Springs to Sweetwater (Texas) | 1,090.50 mi (1,754.98 km) |
| Homosassa Springs to Sycamore (Illinois) | 973.69 mi (1,567.00 km) |
| Homosassa Springs to Sylacauga (Alabama) | 373.53 mi (601.15 km) |
| Homosassa Springs to Sylvania (Ohio) | 893.59 mi (1,438.09 km) |
| Homosassa Springs to Syosset (New York) | 973.73 mi (1,567.06 km) |
| Homosassa Springs to Syracuse (New York) | 1,045.37 mi (1,682.37 km) |
| Homosassa Springs to Syracuse (Utah) | 1,862.53 mi (2,997.46 km) |
