| Homosassa Springs to Storm Lake (Iowa) | 1,187.55 mi (1,911.18 km) |
| Homosassa Springs to Storrs (Connecticut) | 1,067.18 mi (1,717.46 km) |
| Homosassa Springs to Stoughton (Wisconsin) | 1,043.47 mi (1,679.31 km) |
| Homosassa Springs to Stow (Ohio) | 856.57 mi (1,378.52 km) |
| Homosassa Springs to Streamwood (Illinois) | 965.71 mi (1,554.16 km) |
| Homosassa Springs to Streator (Illinois) | 921.59 mi (1,483.15 km) |
| Homosassa Springs to Streetsboro (Ohio) | 861.30 mi (1,386.12 km) |
| Homosassa Springs to Strongsville (Ohio) | 864.65 mi (1,391.51 km) |
| Homosassa Springs to Stuart (Florida) | 179.06 mi (288.16 km) |
| Homosassa Springs to Stuarts Draft (Virginia) | 667.30 mi (1,073.92 km) |
| Homosassa Springs to Sturgis (Michigan) | 911.74 mi (1,467.30 km) |
| Homosassa Springs to Suamico (Wisconsin) | 1,134.65 mi (1,826.05 km) |
| Homosassa Springs to Sudley (Virginia) | 747.27 mi (1,202.62 km) |
| Homosassa Springs to Suffern (New York) | 972.76 mi (1,565.50 km) |
| Homosassa Springs to Suffolk (Virginia) | 643.24 mi (1,035.19 km) |
