| Homosassa Springs to Southern Pines (North Carolina) | 477.53 mi (768.51 km) |
| Homosassa Springs to Southfield (Michigan) | 944.99 mi (1,520.81 km) |
| Homosassa Springs to Southgate (Michigan) | 926.10 mi (1,490.42 km) |
| Homosassa Springs to Southlake (Texas) | 911.49 mi (1,466.90 km) |
| Homosassa Springs to Spanaway (Washington) | 2,475.81 mi (3,984.43 km) |
| Homosassa Springs to Spanish Fork (Utah) | 1,821.28 mi (2,931.06 km) |
| Homosassa Springs to Spanish Lake (Missouri) | 817.17 mi (1,315.10 km) |
| Homosassa Springs to Spanish Springs (Nevada) | 2,230.83 mi (3,590.18 km) |
| Homosassa Springs to Sparks (Nevada) | 2,232.50 mi (3,592.86 km) |
| Homosassa Springs to Spartanburg (South Carolina) | 425.23 mi (684.34 km) |
| Homosassa Springs to Spearfish (South Dakota) | 1,592.35 mi (2,562.64 km) |
| Homosassa Springs to Speedway (Indiana) | 787.53 mi (1,267.41 km) |
| Homosassa Springs to Spencer (Iowa) | 1,212.85 mi (1,951.89 km) |
| Homosassa Springs to Spokane (Washington) | 2,268.56 mi (3,650.89 km) |
| Homosassa Springs to Spokane Valley (Washington) | 2,259.91 mi (3,636.98 km) |
