| Homosassa Springs to Seymour (Tennessee) | 493.46 mi (794.14 km) |
| Homosassa Springs to Shady Hills (Florida) | 28.17 mi (45.34 km) |
| Homosassa Springs to Shafter (California) | 2,180.66 mi (3,509.44 km) |
| Homosassa Springs to Shaker Heights (Ohio) | 876.66 mi (1,410.85 km) |
| Homosassa Springs to Shakopee (Minnesota) | 1,255.35 mi (2,020.29 km) |
| Homosassa Springs to Sharon (Pennsylvania) | 865.93 mi (1,393.58 km) |
| Homosassa Springs to Sharonville (Ohio) | 731.26 mi (1,176.84 km) |
| Homosassa Springs to Shasta Lake (California) | 2,382.02 mi (3,833.49 km) |
| Homosassa Springs to Shawnee (Kansas) | 994.10 mi (1,599.84 km) |
| Homosassa Springs to Shawnee (Oklahoma) | 956.38 mi (1,539.15 km) |
| Homosassa Springs to Sheboygan (Wisconsin) | 1,070.65 mi (1,723.04 km) |
| Homosassa Springs to Shelby (North Carolina) | 451.38 mi (726.43 km) |
| Homosassa Springs to Shelbyville (Indiana) | 763.55 mi (1,228.81 km) |
| Homosassa Springs to Shelbyville (Kentucky) | 667.27 mi (1,073.86 km) |
| Homosassa Springs to Shelbyville (Tennessee) | 515.46 mi (829.55 km) |
