| Homosassa Springs to Security-Widefield (Colorado) | 1,441.27 mi (2,319.51 km) |
| Homosassa Springs to Sedalia (Missouri) | 917.71 mi (1,476.92 km) |
| Homosassa Springs to Sedro-Woolley (Washington) | 2,496.45 mi (4,017.64 km) |
| Homosassa Springs to Seguin (Texas) | 931.39 mi (1,498.93 km) |
| Homosassa Springs to Selden (New York) | 990.55 mi (1,594.14 km) |
| Homosassa Springs to Selma (Alabama) | 365.23 mi (587.79 km) |
| Homosassa Springs to Selma (California) | 2,206.94 mi (3,551.73 km) |
| Homosassa Springs to Selma (Texas) | 952.16 mi (1,532.35 km) |
| Homosassa Springs to Seminole (Florida) | 68.55 mi (110.31 km) |
| Homosassa Springs to Seven Hills (Ohio) | 869.76 mi (1,399.74 km) |
| Homosassa Springs to Seven Oaks (South Carolina) | 370.97 mi (597.02 km) |
| Homosassa Springs to Severn (Maryland) | 787.49 mi (1,267.35 km) |
| Homosassa Springs to Severna Park (Maryland) | 787.62 mi (1,267.55 km) |
| Homosassa Springs to Sevierville (Tennessee) | 492.52 mi (792.63 km) |
| Homosassa Springs to Seymour (Indiana) | 726.07 mi (1,168.49 km) |
