| Homosassa Springs to Scottsboro (Alabama) | 452.58 mi (728.36 km) |
| Homosassa Springs to Scottsdale (Arizona) | 1,758.52 mi (2,830.07 km) |
| Homosassa Springs to Scranton (Pennsylvania) | 952.05 mi (1,532.18 km) |
| Homosassa Springs to Seabrook (Maryland) | 774.18 mi (1,245.93 km) |
| Homosassa Springs to Seabrook (Texas) | 754.49 mi (1,214.24 km) |
| Homosassa Springs to Seaford (New York) | 965.61 mi (1,553.99 km) |
| Homosassa Springs to Seagoville (Texas) | 872.33 mi (1,403.88 km) |
| Homosassa Springs to Seal Beach (California) | 2,115.15 mi (3,404.01 km) |
| Homosassa Springs to Searcy (Arkansas) | 697.64 mi (1,122.74 km) |
| Homosassa Springs to Seaside (California) | 2,329.32 mi (3,748.69 km) |
| Homosassa Springs to SeaTac (Washington) | 2,477.05 mi (3,986.43 km) |
| Homosassa Springs to Seattle (Washington) | 2,481.77 mi (3,994.03 km) |
| Homosassa Springs to Sebastian (Florida) | 143.96 mi (231.69 km) |
| Homosassa Springs to Sebring (Florida) | 113.51 mi (182.68 km) |
| Homosassa Springs to Secaucus (New Jersey) | 955.42 mi (1,537.61 km) |
