| Homosassa Springs to Santa Rosa (California) | 2,384.21 mi (3,837.02 km) |
| Homosassa Springs to Santaquin (Utah) | 1,826.42 mi (2,939.33 km) |
| Homosassa Springs to Santee (California) | 2,053.50 mi (3,304.80 km) |
| Homosassa Springs to Sapulpa (Oklahoma) | 932.92 mi (1,501.40 km) |
| Homosassa Springs to Saraland (Alabama) | 361.74 mi (582.16 km) |
| Homosassa Springs to Sarasota (Florida) | 101.79 mi (163.81 km) |
| Homosassa Springs to Sarasota Springs (Florida) | 103.94 mi (167.27 km) |
| Homosassa Springs to Saratoga (California) | 2,342.47 mi (3,769.84 km) |
| Homosassa Springs to Saratoga Springs (New York) | 1,098.64 mi (1,768.09 km) |
| Homosassa Springs to Saratoga Springs (Utah) | 1,839.77 mi (2,960.82 km) |
| Homosassa Springs to Sartell (Minnesota) | 1,324.00 mi (2,130.76 km) |
| Homosassa Springs to Satellite Beach (Florida) | 125.52 mi (202.01 km) |
| Homosassa Springs to Sauk Rapids (Minnesota) | 1,321.05 mi (2,126.02 km) |
| Homosassa Springs to Sault Ste. Marie (Michigan) | 1,224.89 mi (1,971.26 km) |
| Homosassa Springs to Savage (Minnesota) | 1,251.21 mi (2,013.62 km) |
