| Homosassa Springs to Orangevale (California) | 2,305.57 mi (3,710.45 km) |
| Homosassa Springs to Orchards (Washington) | 2,455.03 mi (3,950.99 km) |
| Homosassa Springs to Orcutt (California) | 2,248.99 mi (3,619.40 km) |
| Homosassa Springs to Oregon (Ohio) | 888.61 mi (1,430.08 km) |
| Homosassa Springs to Oregon (Wisconsin) | 1,046.91 mi (1,684.84 km) |
| Homosassa Springs to Oregon City (Oregon) | 2,452.11 mi (3,946.29 km) |
| Homosassa Springs to Orem (Utah) | 1,827.94 mi (2,941.78 km) |
| Homosassa Springs to Orinda (California) | 2,353.09 mi (3,786.92 km) |
| Homosassa Springs to Orland Park (Illinois) | 933.24 mi (1,501.91 km) |
| Homosassa Springs to Orlando (Florida) | 76.48 mi (123.08 km) |
| Homosassa Springs to Ormond Beach (Florida) | 93.12 mi (149.86 km) |
| Homosassa Springs to Oro Valley (Arizona) | 1,704.12 mi (2,742.51 km) |
| Homosassa Springs to Oroville (California) | 2,329.55 mi (3,749.04 km) |
| Homosassa Springs to Oshkosh (Wisconsin) | 1,102.22 mi (1,773.85 km) |
| Homosassa Springs to Oskaloosa (Iowa) | 1,032.72 mi (1,662.01 km) |
