| Homosassa Springs to Olympia Heights (Florida) | 252.53 mi (406.41 km) |
| Homosassa Springs to Omaha (Nebraska) | 1,148.00 mi (1,847.53 km) |
| Homosassa Springs to On Top of the World Designated Place (Florida) | 25.41 mi (40.89 km) |
| Homosassa Springs to Onalaska (Wisconsin) | 1,146.34 mi (1,844.85 km) |
| Homosassa Springs to Oneida (New York) | 1,057.06 mi (1,701.18 km) |
| Homosassa Springs to Oneonta (New York) | 1,030.77 mi (1,658.86 km) |
| Homosassa Springs to Ontario (California) | 2,088.44 mi (3,361.02 km) |
| Homosassa Springs to Ontario (Oregon) | 2,161.98 mi (3,479.37 km) |
| Homosassa Springs to Opa-locka (Florida) | 245.21 mi (394.62 km) |
| Homosassa Springs to Opelika (Alabama) | 314.82 mi (506.65 km) |
| Homosassa Springs to Opelousas (Louisiana) | 584.78 mi (941.12 km) |
| Homosassa Springs to Orange (California) | 2,100.79 mi (3,380.90 km) |
| Homosassa Springs to Orange (Texas) | 680.79 mi (1,095.63 km) |
| Homosassa Springs to Orange City (Florida) | 76.17 mi (122.59 km) |
| Homosassa Springs to Orangeburg (South Carolina) | 338.18 mi (544.24 km) |
