| Homosassa Springs to Enterprise (Nevada) | 1,960.47 mi (3,155.07 km) |
| Homosassa Springs to Enumclaw (Washington) | 2,458.34 mi (3,956.31 km) |
| Homosassa Springs to Ephrata (Pennsylvania) | 864.33 mi (1,391.00 km) |
| Homosassa Springs to Erie (Colorado) | 1,492.24 mi (2,401.53 km) |
| Homosassa Springs to Erie (Pennsylvania) | 929.57 mi (1,496.00 km) |
| Homosassa Springs to Erlanger (Kentucky) | 714.33 mi (1,149.61 km) |
| Homosassa Springs to Escanaba (Michigan) | 1,196.07 mi (1,924.89 km) |
| Homosassa Springs to Escondido (California) | 2,058.13 mi (3,312.24 km) |
| Homosassa Springs to Española (New Mexico) | 1,455.20 mi (2,341.92 km) |
| Homosassa Springs to Essex (Maryland) | 803.86 mi (1,293.69 km) |
| Homosassa Springs to Essex Junction (Vermont) | 1,200.69 mi (1,932.32 km) |
| Homosassa Springs to Estelle (Louisiana) | 461.03 mi (741.96 km) |
| Homosassa Springs to Estero (Florida) | 170.92 mi (275.07 km) |
| Homosassa Springs to Euclid (Ohio) | 884.76 mi (1,423.88 km) |
| Homosassa Springs to Eufaula (Alabama) | 264.67 mi (425.94 km) |
