| Homosassa Springs to Elyria (Ohio) | 868.44 mi (1,397.61 km) |
| Homosassa Springs to Emeryville (California) | 2,359.13 mi (3,796.65 km) |
| Homosassa Springs to Emmaus (Pennsylvania) | 902.64 mi (1,452.66 km) |
| Homosassa Springs to Emporia (Kansas) | 1,025.77 mi (1,650.82 km) |
| Homosassa Springs to Encinitas (California) | 2,069.17 mi (3,330.01 km) |
| Homosassa Springs to Endicott (New York) | 986.89 mi (1,588.25 km) |
| Homosassa Springs to Endwell (New York) | 989.04 mi (1,591.71 km) |
| Homosassa Springs to Englewood (Colorado) | 1,478.99 mi (2,380.21 km) |
| Homosassa Springs to Englewood (Florida) | 127.66 mi (205.44 km) |
| Homosassa Springs to Englewood (New Jersey) | 964.47 mi (1,552.16 km) |
| Homosassa Springs to Englewood (Ohio) | 770.23 mi (1,239.56 km) |
| Homosassa Springs to Enid (Oklahoma) | 1,033.21 mi (1,662.78 km) |
| Homosassa Springs to Ennis (Texas) | 872.20 mi (1,403.67 km) |
| Homosassa Springs to Ensley (Florida) | 307.86 mi (495.45 km) |
| Homosassa Springs to Enterprise (Alabama) | 263.25 mi (423.65 km) |
