| Holyoke to University Place (Washington) | 2,432.27 mi (3,914.35 km) |
| Holyoke to Upland (California) | 2,478.74 mi (3,989.15 km) |
| Holyoke to Upper Arlington (Ohio) | 563.04 mi (906.13 km) |
| Holyoke to Upper Grand Lagoon (Florida) | 1,104.56 mi (1,777.62 km) |
| Holyoke to Upper Montclair (New Jersey) | 124.32 mi (200.07 km) |
| Holyoke to Urbana (Illinois) | 820.91 mi (1,321.12 km) |
| Holyoke to Urbana (Maryland) | 316.54 mi (509.42 km) |
| Holyoke to Urbana (Ohio) | 595.59 mi (958.51 km) |
| Holyoke to Urbandale (Iowa) | 1,084.67 mi (1,745.61 km) |
| Holyoke to Utica (New York) | 144.85 mi (233.11 km) |
| Holyoke to Uvalde (Texas) | 1,756.04 mi (2,826.08 km) |
| Holyoke to Vacaville (California) | 2,577.12 mi (4,147.47 km) |
| Holyoke to Vadnais Heights (Minnesota) | 1,037.62 mi (1,669.88 km) |
| Holyoke to Vail (Arizona) | 2,190.74 mi (3,525.66 km) |
| Holyoke to Valdosta (Georgia) | 980.68 mi (1,578.25 km) |
