| Holyoke to Superior (Colorado) | 1,690.76 mi (2,721.02 km) |
| Holyoke to Superior (Wisconsin) | 1,004.54 mi (1,616.65 km) |
| Holyoke to Surprise (Arizona) | 2,225.86 mi (3,582.17 km) |
| Holyoke to Susanville (California) | 2,459.40 mi (3,958.01 km) |
| Holyoke to Sussex (Wisconsin) | 792.94 mi (1,276.11 km) |
| Holyoke to Suwanee (Georgia) | 837.48 mi (1,347.80 km) |
| Holyoke to Swansea (Illinois) | 945.40 mi (1,521.47 km) |
| Holyoke to Sweetwater (Florida) | 1,217.52 mi (1,959.40 km) |
| Holyoke to Sweetwater (Texas) | 1,657.56 mi (2,667.59 km) |
| Holyoke to Sycamore (Illinois) | 821.22 mi (1,321.63 km) |
| Holyoke to Sylacauga (Alabama) | 969.48 mi (1,560.22 km) |
| Holyoke to Sylvania (Ohio) | 569.31 mi (916.22 km) |
| Holyoke to Syosset (New York) | 106.29 mi (171.06 km) |
| Holyoke to Syracuse (New York) | 187.02 mi (300.97 km) |
| Holyoke to Syracuse (Utah) | 2,018.86 mi (3,249.05 km) |
