| Holyoke to Storm Lake (Iowa) | 1,147.26 mi (1,846.34 km) |
| Holyoke to Storrs (Connecticut) | 34.35 mi (55.29 km) |
| Holyoke to Stoughton (Wisconsin) | 843.81 mi (1,357.98 km) |
| Holyoke to Stow (Ohio) | 459.06 mi (738.79 km) |
| Holyoke to Streamwood (Illinois) | 795.30 mi (1,279.91 km) |
| Holyoke to Streator (Illinois) | 837.65 mi (1,348.06 km) |
| Holyoke to Streetsboro (Ohio) | 453.66 mi (730.10 km) |
| Holyoke to Strongsville (Ohio) | 477.46 mi (768.40 km) |
| Holyoke to Stuart (Florida) | 1,122.64 mi (1,806.71 km) |
| Holyoke to Stuarts Draft (Virginia) | 444.86 mi (715.94 km) |
| Holyoke to Sturgis (Michigan) | 656.01 mi (1,055.75 km) |
| Holyoke to Suamico (Wisconsin) | 790.76 mi (1,272.61 km) |
| Holyoke to Sudley (Virginia) | 347.82 mi (559.76 km) |
| Holyoke to Suffern (New York) | 108.47 mi (174.56 km) |
| Holyoke to Suffolk (Virginia) | 436.70 mi (702.81 km) |
