| Holyoke to Stephenville (Texas) | 1,559.59 mi (2,509.92 km) |
| Holyoke to Sterling (Colorado) | 1,578.35 mi (2,540.10 km) |
| Holyoke to Sterling (Illinois) | 874.61 mi (1,407.54 km) |
| Holyoke to Sterling (Virginia) | 333.89 mi (537.34 km) |
| Holyoke to Sterling Heights (Michigan) | 530.40 mi (853.59 km) |
| Holyoke to Steubenville (Ohio) | 434.83 mi (699.80 km) |
| Holyoke to Stevens Point (Wisconsin) | 862.57 mi (1,388.18 km) |
| Holyoke to Stevenson Ranch (California) | 2,517.81 mi (4,052.02 km) |
| Holyoke to Stillwater (Minnesota) | 1,025.76 mi (1,650.80 km) |
| Holyoke to Stillwater (Oklahoma) | 1,368.97 mi (2,203.15 km) |
| Holyoke to Stockbridge (Georgia) | 870.12 mi (1,400.32 km) |
| Holyoke to Stockton (California) | 2,554.07 mi (4,110.38 km) |
| Holyoke to Stone Ridge (Virginia) | 343.38 mi (552.62 km) |
| Holyoke to Stonecrest (Georgia) | 858.48 mi (1,381.59 km) |
| Holyoke to Stony Brook (New York) | 93.70 mi (150.80 km) |
