| Holyoke to St. Simons (Georgia) | 902.18 mi (1,451.91 km) |
| Holyoke to Stafford (Texas) | 1,541.68 mi (2,481.10 km) |
| Holyoke to Stallings (North Carolina) | 653.64 mi (1,051.93 km) |
| Holyoke to Stamford (Connecticut) | 90.05 mi (144.93 km) |
| Holyoke to Stanford (California) | 2,611.99 mi (4,203.59 km) |
| Holyoke to Stanton (California) | 2,505.68 mi (4,032.50 km) |
| Holyoke to Star (Idaho) | 2,193.70 mi (3,530.43 km) |
| Holyoke to Starkville (Mississippi) | 1,067.59 mi (1,718.12 km) |
| Holyoke to State College (Pennsylvania) | 287.15 mi (462.12 km) |
| Holyoke to Staten Island (New York) | 137.04 mi (220.55 km) |
| Holyoke to Statesboro (Georgia) | 840.32 mi (1,352.36 km) |
| Holyoke to Statesville (North Carolina) | 625.97 mi (1,007.40 km) |
| Holyoke to Staunton (Virginia) | 439.39 mi (707.13 km) |
| Holyoke to Steamboat Springs (Colorado) | 1,765.29 mi (2,840.96 km) |
| Holyoke to Steiner Ranch (Texas) | 1,618.15 mi (2,604.16 km) |
