| Holyoke to Southern Pines (North Carolina) | 606.36 mi (975.84 km) |
| Holyoke to Southfield (Michigan) | 542.26 mi (872.68 km) |
| Holyoke to Southgate (Michigan) | 540.33 mi (869.57 km) |
| Holyoke to Southlake (Texas) | 1,479.48 mi (2,380.99 km) |
| Holyoke to Spanaway (Washington) | 2,428.09 mi (3,907.63 km) |
| Holyoke to Spanish Fork (Utah) | 2,016.14 mi (3,244.67 km) |
| Holyoke to Spanish Lake (Missouri) | 950.86 mi (1,530.25 km) |
| Holyoke to Spanish Springs (Nevada) | 2,429.86 mi (3,910.48 km) |
| Holyoke to Sparks (Nevada) | 2,434.15 mi (3,917.38 km) |
| Holyoke to Spartanburg (South Carolina) | 708.85 mi (1,140.78 km) |
| Holyoke to Spearfish (South Dakota) | 1,564.57 mi (2,517.94 km) |
| Holyoke to Speedway (Indiana) | 728.06 mi (1,171.70 km) |
| Holyoke to Spencer (Iowa) | 1,141.87 mi (1,837.67 km) |
| Holyoke to Spokane (Washington) | 2,191.40 mi (3,526.72 km) |
| Holyoke to Spokane Valley (Washington) | 2,182.27 mi (3,512.03 km) |
