| Holyoke to Smyrna (Delaware) | 254.51 mi (409.60 km) |
| Holyoke to Smyrna (Georgia) | 864.73 mi (1,391.65 km) |
| Holyoke to Smyrna (Tennessee) | 858.99 mi (1,382.40 km) |
| Holyoke to Snellville (Georgia) | 844.59 mi (1,359.23 km) |
| Holyoke to Snoqualmie (Washington) | 2,395.95 mi (3,855.91 km) |
| Holyoke to Snyder (Texas) | 1,673.64 mi (2,693.47 km) |
| Holyoke to Socastee (South Carolina) | 683.12 mi (1,099.38 km) |
| Holyoke to Socorro (Texas) | 1,979.68 mi (3,185.99 km) |
| Holyoke to Soddy-Daisy (Tennessee) | 827.56 mi (1,331.83 km) |
| Holyoke to Solana Beach (California) | 2,493.73 mi (4,013.28 km) |
| Holyoke to Soledad (California) | 2,597.55 mi (4,180.35 km) |
| Holyoke to Solon (Ohio) | 456.58 mi (734.80 km) |
| Holyoke to Somers Point (New Jersey) | 224.95 mi (362.03 km) |
| Holyoke to Somerset (Kentucky) | 727.79 mi (1,171.26 km) |
| Holyoke to Somerset (New Jersey) | 152.20 mi (244.94 km) |
