| Holyoke to Silver Firs (Washington) | 2,406.23 mi (3,872.46 km) |
| Holyoke to Silver Spring (Maryland) | 319.22 mi (513.74 km) |
| Holyoke to Silver Springs Shores (Florida) | 1,045.39 mi (1,682.39 km) |
| Holyoke to Silverdale (Washington) | 2,432.95 mi (3,915.45 km) |
| Holyoke to Silverton (Oregon) | 2,475.57 mi (3,984.04 km) |
| Holyoke to Simi Valley (California) | 2,529.81 mi (4,071.33 km) |
| Holyoke to Simpsonville (South Carolina) | 732.52 mi (1,178.88 km) |
| Holyoke to Sioux City (Iowa) | 1,208.79 mi (1,945.37 km) |
| Holyoke to Sioux Falls (South Dakota) | 1,218.92 mi (1,961.66 km) |
| Holyoke to Skokie (Illinois) | 772.84 mi (1,243.77 km) |
| Holyoke to Sleepy Hollow (New York) | 100.08 mi (161.06 km) |
| Holyoke to Slidell (Louisiana) | 1,256.97 mi (2,022.90 km) |
| Holyoke to Smithfield (North Carolina) | 555.17 mi (893.46 km) |
| Holyoke to Smithfield (Utah) | 1,993.46 mi (3,208.16 km) |
| Holyoke to Smithville (Missouri) | 1,160.26 mi (1,867.25 km) |
