| Holyoke to Shelton (Connecticut) | 67.67 mi (108.91 km) |
| Holyoke to Shelton (Washington) | 2,458.31 mi (3,956.27 km) |
| Holyoke to Shenandoah (Louisiana) | 1,303.14 mi (2,097.20 km) |
| Holyoke to Shepherdsville (Kentucky) | 748.58 mi (1,204.72 km) |
| Holyoke to Sheridan (Wyoming) | 1,716.47 mi (2,762.39 km) |
| Holyoke to Sherman (Texas) | 1,428.93 mi (2,299.64 km) |
| Holyoke to Sherrelwood (Colorado) | 1,684.57 mi (2,711.05 km) |
| Holyoke to Sherwood (Arkansas) | 1,169.57 mi (1,882.25 km) |
| Holyoke to Sherwood (Oregon) | 2,472.73 mi (3,979.47 km) |
| Holyoke to Shiloh (Illinois) | 941.82 mi (1,515.71 km) |
| Holyoke to Shiloh (Ohio) | 625.98 mi (1,007.41 km) |
| Holyoke to Shiloh (Pennsylvania) | 265.76 mi (427.70 km) |
| Holyoke to Shirley (New York) | 98.78 mi (158.97 km) |
| Holyoke to Shively (Kentucky) | 747.42 mi (1,202.86 km) |
| Holyoke to Shoreline (Washington) | 2,416.29 mi (3,888.65 km) |
