| Holyoke to Seymour (Tennessee) | 739.22 mi (1,189.66 km) |
| Holyoke to Shady Hills (Florida) | 1,103.69 mi (1,776.21 km) |
| Holyoke to Shafter (California) | 2,516.43 mi (4,049.80 km) |
| Holyoke to Shaker Heights (Ohio) | 461.15 mi (742.16 km) |
| Holyoke to Shakopee (Minnesota) | 1,056.26 mi (1,699.89 km) |
| Holyoke to Sharon (Pennsylvania) | 410.71 mi (660.98 km) |
| Holyoke to Sharonville (Ohio) | 647.66 mi (1,042.31 km) |
| Holyoke to Shasta Lake (California) | 2,541.04 mi (4,089.40 km) |
| Holyoke to Shawnee (Kansas) | 1,179.90 mi (1,898.86 km) |
| Holyoke to Shawnee (Oklahoma) | 1,387.32 mi (2,232.68 km) |
| Holyoke to Sheboygan (Wisconsin) | 769.01 mi (1,237.60 km) |
| Holyoke to Shelby (North Carolina) | 676.70 mi (1,089.05 km) |
| Holyoke to Shelbyville (Indiana) | 710.08 mi (1,142.76 km) |
| Holyoke to Shelbyville (Kentucky) | 718.67 mi (1,156.59 km) |
| Holyoke to Shelbyville (Tennessee) | 874.32 mi (1,407.08 km) |
