| Holyoke to Security-Widefield (Colorado) | 1,692.33 mi (2,723.54 km) |
| Holyoke to Sedalia (Missouri) | 1,106.43 mi (1,780.63 km) |
| Holyoke to Sedro-Woolley (Washington) | 2,402.94 mi (3,867.16 km) |
| Holyoke to Seguin (Texas) | 1,654.56 mi (2,662.76 km) |
| Holyoke to Selden (New York) | 95.00 mi (152.89 km) |
| Holyoke to Selma (Alabama) | 1,038.36 mi (1,671.09 km) |
| Holyoke to Selma (California) | 2,506.25 mi (4,033.42 km) |
| Holyoke to Selma (Texas) | 1,670.91 mi (2,689.06 km) |
| Holyoke to Seminole (Florida) | 1,144.73 mi (1,842.27 km) |
| Holyoke to Seven Hills (Ohio) | 468.58 mi (754.11 km) |
| Holyoke to Seven Oaks (South Carolina) | 728.44 mi (1,172.31 km) |
| Holyoke to Severn (Maryland) | 300.50 mi (483.60 km) |
| Holyoke to Severna Park (Maryland) | 298.30 mi (480.07 km) |
| Holyoke to Sevierville (Tennessee) | 730.27 mi (1,175.26 km) |
| Holyoke to Seymour (Indiana) | 730.08 mi (1,174.94 km) |
