| Holyoke to Scottsboro (Alabama) | 892.76 mi (1,436.75 km) |
| Holyoke to Scottsdale (Arizona) | 2,195.69 mi (3,533.63 km) |
| Holyoke to Scranton (Pennsylvania) | 165.42 mi (266.22 km) |
| Holyoke to Seabrook (Maryland) | 313.99 mi (505.32 km) |
| Holyoke to Seabrook (Texas) | 1,519.40 mi (2,445.24 km) |
| Holyoke to Seaford (New York) | 115.47 mi (185.83 km) |
| Holyoke to Seagoville (Texas) | 1,461.50 mi (2,352.06 km) |
| Holyoke to Seal Beach (California) | 2,511.11 mi (4,041.24 km) |
| Holyoke to Searcy (Arkansas) | 1,132.93 mi (1,823.28 km) |
| Holyoke to Seaside (California) | 2,616.66 mi (4,211.12 km) |
| Holyoke to SeaTac (Washington) | 2,418.00 mi (3,891.40 km) |
| Holyoke to Seattle (Washington) | 2,417.06 mi (3,889.88 km) |
| Holyoke to Sebastian (Florida) | 1,090.11 mi (1,754.37 km) |
| Holyoke to Sebring (Florida) | 1,132.57 mi (1,822.69 km) |
| Holyoke to Secaucus (New Jersey) | 123.36 mi (198.53 km) |
