| Holyoke to Savannah (Georgia) | 845.45 mi (1,360.62 km) |
| Holyoke to Sayreville (New Jersey) | 148.95 mi (239.71 km) |
| Holyoke to Sayville (New York) | 103.76 mi (166.99 km) |
| Holyoke to Scaggsville (Maryland) | 307.26 mi (494.49 km) |
| Holyoke to Scarsdale (New York) | 102.85 mi (165.52 km) |
| Holyoke to Schaumburg (Illinois) | 790.43 mi (1,272.07 km) |
| Holyoke to Schenectady (New York) | 77.17 mi (124.19 km) |
| Holyoke to Schererville (Indiana) | 762.57 mi (1,227.24 km) |
| Holyoke to Schertz (Texas) | 1,669.03 mi (2,686.04 km) |
| Holyoke to Schiller Park (Illinois) | 780.02 mi (1,255.32 km) |
| Holyoke to Schofield Barracks (Hawaii) | 5,007.22 mi (8,058.34 km) |
| Holyoke to Scotchtown (New York) | 102.35 mi (164.71 km) |
| Holyoke to Scottdale (Georgia) | 857.95 mi (1,380.73 km) |
| Holyoke to Scotts Valley (California) | 2,614.28 mi (4,207.27 km) |
| Holyoke to Scottsbluff (Nebraska) | 1,583.10 mi (2,547.75 km) |
