| Holyoke to Santa Rosa (California) | 2,611.96 mi (4,203.55 km) |
| Holyoke to Santaquin (Utah) | 2,026.75 mi (3,261.74 km) |
| Holyoke to Santee (California) | 2,484.31 mi (3,998.12 km) |
| Holyoke to Sapulpa (Oklahoma) | 1,323.63 mi (2,130.17 km) |
| Holyoke to Saraland (Alabama) | 1,159.84 mi (1,866.58 km) |
| Holyoke to Sarasota (Florida) | 1,169.33 mi (1,881.85 km) |
| Holyoke to Sarasota Springs (Florida) | 1,169.36 mi (1,881.90 km) |
| Holyoke to Saratoga (California) | 2,609.15 mi (4,199.02 km) |
| Holyoke to Saratoga Springs (New York) | 82.61 mi (132.95 km) |
| Holyoke to Saratoga Springs (Utah) | 2,025.30 mi (3,259.41 km) |
| Holyoke to Sartell (Minnesota) | 1,095.95 mi (1,763.77 km) |
| Holyoke to Satellite Beach (Florida) | 1,067.56 mi (1,718.06 km) |
| Holyoke to Sauk Rapids (Minnesota) | 1,092.62 mi (1,758.40 km) |
| Holyoke to Sault Ste. Marie (Michigan) | 649.47 mi (1,045.22 km) |
| Holyoke to Savage (Minnesota) | 1,050.62 mi (1,690.80 km) |
