| Holyoke to Sanford (Maine) | 126.98 mi (204.36 km) |
| Holyoke to Sanford (North Carolina) | 582.34 mi (937.18 km) |
| Holyoke to Sanger (California) | 2,499.83 mi (4,023.08 km) |
| Holyoke to Santa Ana (California) | 2,501.97 mi (4,026.53 km) |
| Holyoke to Santa Barbara (California) | 2,574.42 mi (4,143.13 km) |
| Holyoke to Santa Clara (California) | 2,603.58 mi (4,190.06 km) |
| Holyoke to Santa Clara (Oregon) | 2,507.73 mi (4,035.80 km) |
| Holyoke to Santa Clarita (California) | 2,512.25 mi (4,043.08 km) |
| Holyoke to Santa Cruz (California) | 2,617.55 mi (4,212.54 km) |
| Holyoke to Santa Fe (New Mexico) | 1,835.43 mi (2,953.85 km) |
| Holyoke to Santa Fe (Texas) | 1,531.36 mi (2,464.49 km) |
| Holyoke to Santa Fe Springs (California) | 2,505.06 mi (4,031.50 km) |
| Holyoke to Santa Maria (California) | 2,595.95 mi (4,177.77 km) |
| Holyoke to Santa Monica (California) | 2,523.63 mi (4,061.39 km) |
| Holyoke to Santa Paula (California) | 2,543.27 mi (4,092.99 km) |
