| Holyoke to San Luis Obispo (California) | 2,597.47 mi (4,180.22 km) |
| Holyoke to San Marcos (California) | 2,484.93 mi (3,999.11 km) |
| Holyoke to San Marcos (Texas) | 1,640.85 mi (2,640.68 km) |
| Holyoke to San Marino (California) | 2,501.75 mi (4,026.18 km) |
| Holyoke to San Mateo (California) | 2,615.84 mi (4,209.78 km) |
| Holyoke to San Pablo (California) | 2,606.36 mi (4,194.53 km) |
| Holyoke to San Rafael (California) | 2,614.66 mi (4,207.88 km) |
| Holyoke to San Ramon (California) | 2,591.26 mi (4,170.23 km) |
| Holyoke to San Tan Valley (Arizona) | 2,196.52 mi (3,534.96 km) |
| Holyoke to Sand Springs (Oklahoma) | 1,321.23 mi (2,126.32 km) |
| Holyoke to Sandusky (Ohio) | 520.38 mi (837.47 km) |
| Holyoke to Sandy (Oregon) | 2,445.03 mi (3,934.90 km) |
| Holyoke to Sandy (Utah) | 2,017.60 mi (3,247.01 km) |
| Holyoke to Sandy Springs (Georgia) | 855.22 mi (1,376.35 km) |
| Holyoke to Sanford (Florida) | 1,045.56 mi (1,682.67 km) |
