| Holyoke to Salisbury (New York) | 111.98 mi (180.21 km) |
| Holyoke to Salisbury (North Carolina) | 617.96 mi (994.51 km) |
| Holyoke to Salmon Creek (Washington) | 2,458.80 mi (3,957.06 km) |
| Holyoke to Salt Lake City (Utah) | 2,017.67 mi (3,247.13 km) |
| Holyoke to Sammamish (Washington) | 2,404.31 mi (3,869.36 km) |
| Holyoke to San Angelo (Texas) | 1,698.10 mi (2,732.83 km) |
| Holyoke to San Anselmo (California) | 2,617.28 mi (4,212.11 km) |
| Holyoke to San Antonio (Texas) | 1,686.12 mi (2,713.55 km) |
| Holyoke to San Benito (Texas) | 1,798.66 mi (2,894.66 km) |
| Holyoke to San Bernardino (California) | 2,459.29 mi (3,957.84 km) |
| Holyoke to San Bruno (California) | 2,619.86 mi (4,216.25 km) |
| Holyoke to San Buenaventura (California) | 2,554.21 mi (4,110.61 km) |
| Holyoke to San Carlos (California) | 2,615.06 mi (4,208.54 km) |
| Holyoke to San Carlos Park (Florida) | 1,204.96 mi (1,939.19 km) |
| Holyoke to San Clemente (California) | 2,497.15 mi (4,018.77 km) |
