| Holyoke to Saddlebrooke (Arizona) | 2,181.80 mi (3,511.26 km) |
| Holyoke to Safety Harbor (Florida) | 1,132.18 mi (1,822.07 km) |
| Holyoke to Saginaw (Michigan) | 578.74 mi (931.40 km) |
| Holyoke to Saginaw (Texas) | 1,493.29 mi (2,403.22 km) |
| Holyoke to Sahuarita (Arizona) | 2,207.63 mi (3,552.84 km) |
| Holyoke to Saks (Alabama) | 927.06 mi (1,491.96 km) |
| Holyoke to Salem (Massachusetts) | 91.17 mi (146.73 km) |
| Holyoke to Salem (Ohio) | 433.69 mi (697.96 km) |
| Holyoke to Salem (Oregon) | 2,488.45 mi (4,004.77 km) |
| Holyoke to Salem (Virginia) | 520.19 mi (837.16 km) |
| Holyoke to Salem Lakes (Wisconsin) | 789.85 mi (1,271.14 km) |
| Holyoke to Salida (California) | 2,549.73 mi (4,103.40 km) |
| Holyoke to Salina (Kansas) | 1,327.70 mi (2,136.73 km) |
| Holyoke to Salinas (California) | 2,605.28 mi (4,192.80 km) |
| Holyoke to Salisbury (Maryland) | 307.15 mi (494.32 km) |
