| Holyoke to Reidsville (North Carolina) | 552.96 mi (889.90 km) |
| Holyoke to Reisterstown (Maryland) | 289.57 mi (466.01 km) |
| Holyoke to Rendon (Texas) | 1,497.76 mi (2,410.41 km) |
| Holyoke to Reno (Nevada) | 2,441.33 mi (3,928.94 km) |
| Holyoke to Renton (Washington) | 2,412.68 mi (3,882.83 km) |
| Holyoke to Republic (Missouri) | 1,156.91 mi (1,861.86 km) |
| Holyoke to Reston (Virginia) | 334.23 mi (537.90 km) |
| Holyoke to Revere (Massachusetts) | 84.85 mi (136.55 km) |
| Holyoke to Rexburg (Idaho) | 1,962.40 mi (3,158.17 km) |
| Holyoke to Reynoldsburg (Ohio) | 550.81 mi (886.45 km) |
| Holyoke to Rialto (California) | 2,464.88 mi (3,966.85 km) |
| Holyoke to Richardson (Texas) | 1,457.35 mi (2,345.38 km) |
| Holyoke to Richfield (Minnesota) | 1,047.06 mi (1,685.08 km) |
| Holyoke to Richfield (Wisconsin) | 793.82 mi (1,277.53 km) |
| Holyoke to Richland (Washington) | 2,292.45 mi (3,689.35 km) |
