| Holyoke to Oswego (Illinois) | 806.28 mi (1,297.59 km) |
| Holyoke to Oswego (New York) | 213.45 mi (343.51 km) |
| Holyoke to Otsego (Minnesota) | 1,065.09 mi (1,714.09 km) |
| Holyoke to Ottawa (Illinois) | 834.70 mi (1,343.31 km) |
| Holyoke to Ottawa (Kansas) | 1,212.30 mi (1,951.01 km) |
| Holyoke to Ottumwa (Iowa) | 1,022.62 mi (1,645.75 km) |
| Holyoke to Overland (Missouri) | 961.20 mi (1,546.89 km) |
| Holyoke to Overland Park (Kansas) | 1,176.50 mi (1,893.40 km) |
| Holyoke to Overlea (Maryland) | 282.52 mi (454.67 km) |
| Holyoke to Oviedo (Florida) | 1,051.51 mi (1,692.24 km) |
| Holyoke to Owasso (Oklahoma) | 1,301.74 mi (2,094.95 km) |
| Holyoke to Owatonna (Minnesota) | 1,043.19 mi (1,678.85 km) |
| Holyoke to Owensboro (Kentucky) | 824.53 mi (1,326.95 km) |
| Holyoke to Owings Mills (Maryland) | 290.72 mi (467.86 km) |
| Holyoke to Owosso (Michigan) | 588.64 mi (947.33 km) |
